Marcus Whitman left his mark on Oregon Country as an early missionary to Cayuse people on the Columbia Plateau and as an advocate for American settlement of the region. His name is famous for the incident of his death at the hands of Cayuse antagonists in 1847. His name is also affixed to a county in Washington State and a liberal arts college in Walla Walla, Washington.

Born in 1802, Whitman experienced a difficult boyhood separated from parents, and religious relatives and Congregational minister Rev. Moses Hallock contributed to his deep Christian faith. Unable to afford training as a minister, Whitman attained a degree from reputable Fairfield Medical College in 1832 and applied to serve as a medical missionary for the American Board of Commissioners for Foreign Missions (ABCFM). In 1835, he and Rev. Samuel Parker were sent on a reconnaissance to determine if Oregon Country Indians desired missionaries. They met Nez Perce and Natives who desired a mission, and Whitman persuaded the ABCFM to send missionaries, including his new bride Narcissa, Reverend Henry Spalding, his wife Eliza, and William Gray. In 1836, the Whitmans established a mission at Waiilatpu in the Walla Walla Valley, while the Spaldings established their mission at Lapwai near the Clearwater River in present-day Idaho.

Whitman lacked theological training, so he could not baptize anyone, but he ministered by using his considerable Sunday school experience, telling Bible stories and teaching devotional songs. Many Cayuse enjoyed these activities, but they consistently rejected his strict Calvinism while Whitman opposed Indian spiritualism, prompting religious disagreements. The Cayuse, however, were more willing to follow his agricultural teachings. Whitman traveled extensively as a physician providing drugs to missionaries and Natives, but he was dismayed when his Cayuse patients combined his treatments with those of shamans.

Whitman’s efforts at Waiilatpu soon became problematic. In 1838, a reinforcement of three missionary couples arrived, including Rev. Asa Smith, who quarreled with Whitman about missionary strategies. Smith’s negative correspondence to the ABCFM influenced its Oregon policy, and the arrival of Roman Catholic priests in Oregon posed competition for Indian converts. The following year, his daughter, Alice Clarissa, drowned. The distressed parents would not have another child, but they reared two girls of mixed ancestry. In 1841, an angry Cauyse chief struck Whitman and pulled his ears, a result of a disagreement when a few Cayuse leaders insisted on payment for occupying their land.

By the early 1840s, it was obvious that the Whitmans had failed to Christianize and acculturate the Cayuse. Marcus and Narcissa, like most Americans, were culturally arrogant. Frustration led Whitman to consider resignation, but he feared Catholics would occupy Waiilatpu. Furthermore, he believed a closure would weaken the American claim to Oregon. Thus the overworked couple continued to pursue unattainable goals.  

In 1842, ABCFM reacted to negative letters from missionaries by recalling Smith and Gray, dismissing Spalding, and transferring Whitman to Tshimakain to join colleagues Cyrus Walker and Cushing Eells.  Whitman traveled east and persuaded the ABCFM to rescind its orders. An ardent expansionist, he was certain that Oregon could be reached by wagon, and he urged Christian families to settle near Waiilaptu where they could help convert the Indians. Whitman served as guide and physician for a wagon train in 1843 that brought about a thousand settlers to Oregon.  

From 1844 until his murder three years later, Whitman continued missionary tasks and provided food and sanctuary for immigrants. The Cayuse rightly worried about displacement by migrating whites, and the Whitmans’ concentrated aid to whites and their neglect of the Indians. Ironically, by encouraging immigration and expansion, Whitman jeopardized the future of the Cayuse and his mission. Aware of his declining status, he pondered resigning in 1845, but he was an optimist and continued to insist that whites and Indians could share the land.

In the fall of 1847, a measles epidemic introduced by tribesmen—not by overlanders—led to massive deaths among the Cayuse. Some Cayuse blamed Whitman for being a failed shaman or a murderer who administered poison, and they killed Marcus, Narcissa, and twelve others on November 29, 1847. The event led to the Cayuse War, which ended with the surrender, court judgment, and execution of five Cayuse men.